Human islet T cells are highly reactive to preproinsulin in type 1 diabetes
نویسندگان
چکیده
Brief Summary: This in vitro study explored the reactivity to preproinsulin of CD8 T cells obtained from pancreatic islets individuals with and without type 1 diabetes (T1D). The main finding was that T1D donors were highly reactive peptides throughout entire protein.
منابع مشابه
Islet Amyloid Polypeptide is not a Target Antigen for CD8+ T-Cells in Type 2 Diabetes
Background: Type 2 diabetes (T2D) is a chronic metabolic disorder in which beta-cells are destroyed. The islet amyloid polypeptide (IAPP) produced by beta-cells has been reported to influence beta-cell destruction. Objective: To evaluate if IAPP can act as an autoantigen and therefore, to see if CD8 + T-cells specific for this protein might be present in T2D patients. Methods: Peripheral blood ...
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background: type 2 diabetes (t2d) is a chronic metabolic disorder in which beta-cells are destroyed. the islet amyloid polypeptide (iapp) produced by beta-cells has been reported to influence beta-cell destruction. objective: to evaluate if iapp can act as an autoantigen and therefore, to see if cd8 + t-cells specific for this protein might be present in t2d patients. methods: peripheral blood ...
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ژورنال
عنوان ژورنال: Yearbook of pediatric endocrinology
سال: 2022
ISSN: ['1662-3991', '1662-4009']
DOI: https://doi.org/10.1530/ey.19.10.13